A remote code execution vulnerability exists within multiple subsystems of Drupal 7.x and 8.x. This potentially allows attackers to exploit multiple attack vectors on a Drupal site, which could result in the site being completely compromised.
The security team has written an [FAQ](https://groups.drupal.org/security/faq-2018-002) about this issue.
*Edited 2020, February 13 to fix links to patch files.*